Recurrence of intravenous talc granulomatosis following single lung transplantation

Can Respir J. Nov-Dec 1998;5(6):511-4. doi: 10.1155/1998/959750.


Advanced pulmonary disease is an unusual consequence of the intravenous injection of oral medications, usually developing over a period of several years. A number of patients with this condition have undergone lung transplantation for respiratory failure. However, a history of drug abuse is often considered to be a contraindication to transplantation in the context of limited donor resources. A patient with pulmonary talc granulomatosis secondary to intravenous methylphenidate injection who underwent successful lung transplantation and subsequently presented with recurrence of the underlying disease in the transplanted lung 18 months after transplantation is reported.

Publication types

  • Case Reports

MeSH terms

  • Biopsy
  • Central Nervous System Stimulants*
  • Contraindications
  • Female
  • Granuloma, Foreign-Body / etiology*
  • Granuloma, Foreign-Body / surgery
  • Humans
  • Lung Diseases / etiology*
  • Lung Diseases / surgery
  • Lung Transplantation / pathology*
  • Methylphenidate*
  • Middle Aged
  • Recurrence
  • Substance Abuse, Intravenous / complications*
  • Talc / adverse effects*


  • Central Nervous System Stimulants
  • Talc
  • Methylphenidate