Adult resistance to schistosomiasis mansoni: age-dependence of reinfection remains constant in communities with diverse exposure patterns

Parasitology. 1999 Jan;118 ( Pt 1):101-5. doi: 10.1017/s0031182098003576.


In a fishing community on Lake Albert in Uganda the pattern of intensity of Schistosoma mansoni infection 6 months after treatment with praziquantel was found to be very similar to reinfection patterns seen in previously studied endemic communities: the profile peaks sharply at around the age of 10 years falling away rapidly to much lower levels in adults. This is in stark contrast to the patterns of water contact, which differ greatly between fishing and non-fishing communities. On Lake Albert, adults appear to be more heavily exposed than children. From these observations we conclude that adults are physiologically (perhaps immunologically) more resistant to infection after treatment than children.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Animals
  • Antiplatyhelmintic Agents / therapeutic use
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Male
  • Middle Aged
  • Occupational Diseases / drug therapy
  • Occupational Diseases / parasitology*
  • Parasite Egg Count
  • Praziquantel / therapeutic use
  • Schistosoma mansoni / isolation & purification
  • Schistosomiasis mansoni / drug therapy
  • Schistosomiasis mansoni / parasitology*
  • Time Factors
  • Water / parasitology*


  • Antiplatyhelmintic Agents
  • Water
  • Praziquantel