Automated synthesis of [11C]choline, a positron-emitting tracer for tumor imaging

T Hara; M Yuasa

doi:10.1016/s0969-8043(98)00097-9

Automated synthesis of [11C]choline, a positron-emitting tracer for tumor imaging

Appl Radiat Isot. 1999 Mar;50(3):531-3. doi: 10.1016/s0969-8043(98)00097-9.

Authors

T Hara¹, M Yuasa

Affiliation

¹ Department of Radiology, International Medical Center of Japan, Tokyo, Japan.

PMID: 10070713
DOI: 10.1016/s0969-8043(98)00097-9

Abstract

(beta-Hydroxyethyl)tri([11C]methyl)ammonium ([11C]choline) is a tracer very effective in imaging various human tumors using positron emission tomography (PET). We have constructed a computer-controlled [11C]choline synthetic apparatus which carries out the whole process of synthesis and product purification automatically. The setup is simple and the process quick. In 20 min, 11 GBq of [11C]choline (chloride) is obtainable from 26 GBq of [11C]CO2. The final product is a sterile and pyrogen-free [11C]choline "injection".

MeSH terms

Carbon Radioisotopes*
Choline / chemical synthesis*
Humans
Neoplasms / diagnostic imaging*
Radiopharmaceuticals / chemical synthesis*
Technology, Radiologic / instrumentation
Tomography, Emission-Computed / methods*

Substances

Carbon Radioisotopes
Radiopharmaceuticals
Choline