Developments in component-based normalization for 3D PET

Phys Med Biol. 1999 Feb;44(2):571-94. doi: 10.1088/0031-9155/44/2/020.

Abstract

Normalization in positron emission tomography (PET) is the process of ensuring that all lines of response joining detectors in coincidence have the same effective sensitivity. In three-dimensional (3D) PET, normalization is complicated by the presence of a large proportion of scattered coincidences, and by the fact that cameras operating in 3D mode encounter a very wide range of count-rates. In this work a component-based normalization model is presented which separates the normalization of true and scattered coincidences and accounts for variations in normalization effects with count-rate. The effects of the individual components in the model on reconstructed images are investigated, and it is shown that only a subset of these components has a significant effect on reconstructed image quality.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Brain / diagnostic imaging*
  • Computing Methodologies
  • Fluorodeoxyglucose F18
  • Humans
  • Image Processing, Computer-Assisted / methods*
  • Phantoms, Imaging
  • Radiopharmaceuticals
  • Reproducibility of Results
  • Scattering, Radiation
  • Tomography, Emission-Computed*

Substances

  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18