High efficiency of benzoporphyrin derivative in the photodynamic therapy of pigmented malignant melanoma

Br J Cancer. 1999 Feb;79(5-6):821-4. doi: 10.1038/sj.bjc.6690131.

Abstract

Benzoporphyrin derivative monoacid ring A (verteporfin, BPD-MA) when intravenously injected (5.5 micromol kg(-1)) to C57/BL6 mice bearing a subcutaneously transplanted B1 melanoma gave a maximal accumulation in the tumour within 1-3 h with recoveries of 1.84-1.96 micromol kg(-1). Irradiation of BPD-MA-loaded melanoma with 690-nm light from a dye laser at 3 h and 9 h post injection induced tumour necrosis and delay of tumour growth of 28 and 14 days respectively. The response of the tumour to BPD-MA photosensitization was enhanced by pretreatment with 1064-nm light from a pulse-operated Nd:YAG laser, which caused a selective breakdown of melanosomes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacokinetics
  • Antineoplastic Agents / therapeutic use*
  • Cell Division / drug effects
  • Female
  • Light
  • Melanoma, Experimental / drug therapy*
  • Melanoma, Experimental / pathology
  • Mice
  • Mice, Inbred C57BL
  • Necrosis
  • Photochemotherapy*
  • Photosensitizing Agents / pharmacokinetics
  • Photosensitizing Agents / therapeutic use*
  • Porphyrins / pharmacokinetics*
  • Porphyrins / therapeutic use*
  • Time Factors
  • Tissue Distribution
  • Verteporfin

Substances

  • Antineoplastic Agents
  • Photosensitizing Agents
  • Porphyrins
  • Verteporfin