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Clinical Trial
. 1999 Feb;99(2):112-6.
doi: 10.1111/j.1600-0404.1999.tb00667.x.

The Role of Essential Fatty Acids in Chronic Fatigue Syndrome. A Case-Controlled Study of Red-Cell Membrane Essential Fatty Acids (EFA) and a Placebo-Controlled Treatment Study With High Dose of EFA

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Clinical Trial

The Role of Essential Fatty Acids in Chronic Fatigue Syndrome. A Case-Controlled Study of Red-Cell Membrane Essential Fatty Acids (EFA) and a Placebo-Controlled Treatment Study With High Dose of EFA

G Warren et al. Acta Neurol Scand. .

Abstract

Objective: To replicate the treatment study by Behan et al. (1990) using current research criteria for Chronic Fatigue Syndrome (CFS).

Method: Fifty patients who fulfilled the Oxford Criteria for CFS were randomly allocated to treatment with either Efamol Marine or placebo for 3 months. They were seen monthly and completed a physical symptoms checklist and the Beck Inventory for Depression and reported if they were the same, better or worse at the end of the study.

Results: Symptoms generally improved with time but not significantly and there were no significant differences between the treatment and placebo groups. Pretreatment red-cell membrane (RBC) lipids of patients compared with age-and sex-matched normal controls showed no significant differences.

Discussion: The results of this study contrast sharply with the previous study where 85% of patients had a clinically significant improvement of symptoms with Efamol Marine over a 3-month treatment period.

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