Human herpesvirus-8 (HHV-8) associated with small non-cleaved cell lymphoma in a child with AIDS

Am J Hematol. 1999 Mar;60(3):215-21. doi: 10.1002/(sici)1096-8652(199903)60:3<215::aid-ajh8>;2-f.


The association of human herpesvirus-8 (HHV-8) with a small non-cleaved cell lymphoma is described in a child with the acquired immunodeficiency syndrome (AIDS) who developed a malignant pleural effusion and radiologic evidence of multiple solid tumors. HHV-8 DNA and Epstein-Barr virus DNA were identified in pleural fluid cells by polymerase chain reaction (PCR) amplification. The serum antibody titer against lytic HHV-8 proteins was 1:640; antibodies to latent HHV-8 proteins were not detected. Cytogenetic analysis of malignant cells revealed three abnormal karyotypes sharing the common finding of a t(8;14) translocation. Rearrangement of c-myc was demonstrated by PCR analysis. Oligoclonal JH immunoglobulin bands were found. Insufficient pleural fluid cells were available to permit localization of HHV-8 to malignant cells by in situ hybridization. This malignancy contrasts with HHV-8-associated lymphomas reported in adult patients with AIDS with respect to cell morphology, c-myc translocation, and oligoclonal immunoglobulin gene rearrangement. HHV-8 is associated with a wider spectrum of malignancies than recognized previously.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Child, Preschool
  • Chromosomes, Human, Pair 14
  • Chromosomes, Human, Pair 8
  • DNA, Viral / isolation & purification*
  • Female
  • Herpesvirus 8, Human / genetics
  • Herpesvirus 8, Human / isolation & purification*
  • Humans
  • Lymphoma, AIDS-Related / genetics
  • Lymphoma, AIDS-Related / virology*
  • Lymphoma, Non-Hodgkin / genetics
  • Lymphoma, Non-Hodgkin / virology*
  • Male
  • Translocation, Genetic


  • DNA, Viral