Histone acetylases and deacetylases in cell proliferation

Curr Opin Genet Dev. 1999 Feb;9(1):40-8. doi: 10.1016/s0959-437x(99)80006-9.


There are several enzymes, acetylases and deacetylases, that can regulate transcription by modifying the acetylation state of histones or other promoter-bound transcription factors. Some of these enzymes are present in multisubunit complexes. Recent efforts to understand the biological role of these enzymes reveals their involvement in cell-cycle regulation and differentiation. Furthermore, accumulating evidence suggests that deregulation of acetylase and deacetylase activity plays a causative role in the generation of cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetyltransferases / genetics*
  • Acetyltransferases / physiology
  • Animals
  • Cell Division
  • Gene Expression Regulation, Enzymologic
  • Gene Expression Regulation, Neoplastic
  • Histone Acetyltransferases
  • Histone Deacetylases / genetics*
  • Histone Deacetylases / physiology
  • Humans
  • Neoplasms / enzymology
  • Neoplasms / genetics
  • Saccharomyces cerevisiae Proteins*


  • Saccharomyces cerevisiae Proteins
  • Acetyltransferases
  • Histone Acetyltransferases
  • Histone Deacetylases