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. 1999 Feb;9(1):15-21.
doi: 10.1016/s0959-437x(99)80003-3.

The Oncogenic Activation of Beta-Catenin


The Oncogenic Activation of Beta-Catenin

P Polakis. Curr Opin Genet Dev. .


The activation of beta-catenin to an oncogenic state can result from the inactivation of the tumor suppressor adenomatous polyposis coli (APC), by direct mutation in the beta-catenin gene, or by the activation of wnt receptors. Once activated, beta-catenin most likely promotes tumor progression through its persistent interaction with one or more of its numerous downstream targets.

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