The INK4A/ARF locus and its two gene products

Curr Opin Genet Dev. 1999 Feb;9(1):22-30. doi: 10.1016/s0959-437x(99)80004-5.


The INK4A/ARF locus on chromosome 9 is one of the sites mutated most frequently in human cancer. Two genes comprising overlapping reading frames encoding p16(INK4a) and p19(ARF) have been discovered at this locus and, remarkably, both play an important role in regulating cell growth, survival and senescence.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Cyclin-Dependent Kinase Inhibitor p16 / genetics*
  • Genes, Tumor Suppressor / genetics
  • Genes, p16 / genetics*
  • Humans
  • Molecular Sequence Data
  • Mutation
  • Neoplasms / genetics
  • Proteins / genetics*
  • Sequence Homology, Amino Acid
  • Tumor Suppressor Protein p14ARF


  • Cyclin-Dependent Kinase Inhibitor p16
  • Proteins
  • Tumor Suppressor Protein p14ARF