The spindle checkpoint

Curr Opin Genet Dev. 1999 Feb;9(1):69-75. doi: 10.1016/s0959-437x(99)80010-0.


Prior to sister-chromatid separation, the spindle checkpoint inhibits cell-cycle progression in response to a signal generated by mitotic spindle damage or by chromosomes that have not attached to microtubules. Recent work has shown that the spindle checkpoint inhibits cell-cycle progression by direct binding of components of the spindle checkpoint pathway to components of a specialized ubiquitin-conjugating system that is responsible for triggering sister-chromatid separation.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism*
  • Gene Expression Regulation
  • Humans
  • Kinetochores / metabolism
  • Mitosis
  • Models, Genetic
  • Signal Transduction
  • Spindle Apparatus / genetics
  • Spindle Apparatus / physiology*
  • Yeasts


  • Cell Cycle Proteins