Transcriptional control of neurotransmitter phenotype

Curr Opin Neurobiol. 1999 Feb;9(1):47-53. doi: 10.1016/s0959-4388(99)80006-3.


The specification of neurotransmitter phenotype is an important aspect of neuronal fate determination. Recent studies have begun to define essential transcriptional regulators involved in controlling the mode of neurotransmission in vertebrates and invertebrates, and to examine their regulation by cell-extrinsic factors. An emerging concept is that the control of transmitter choice is intimately linked to that of other aspects of the neuronal phenotype.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans
  • Chick Embryo
  • Drosophila
  • Embryonic Induction
  • Genes, Regulator / physiology
  • Neurotransmitter Agents / genetics*
  • Phenotype
  • Transcription Factors / genetics
  • Transcription Factors / physiology*
  • Vertebrates


  • Neurotransmitter Agents
  • Transcription Factors