Control of muscle fibre and motoneuron diversification

Curr Opin Neurobiol. 1999 Feb;9(1):54-64. doi: 10.1016/s0959-4388(99)80007-5.


Recent studies have elucidated both the mechanism of early formation of diverse muscle fibre types and the matching of diverse populations of motoneurons to their appropriate muscle targets. Highlights include the demonstration that distinct signals are necessary for the formation of several distinct myoblast populations in the vertebrate somite, the identification of motoneuron subtypes, studies of how motoneurons target appropriate muscles, and rapid progress on the Drosophila neuromuscular system. We propose a model in which four classes of decision control the patterning of both motoneurons and muscles.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Drosophila
  • Gene Expression Regulation, Developmental*
  • Mice
  • Mice, Transgenic
  • Motor Neurons*
  • Muscle Fibers, Fast-Twitch*
  • Muscle Fibers, Slow-Twitch*
  • Zebrafish