Maternal care and the development of stress responses

Curr Opin Neurobiol. 1999 Feb;9(1):128-34. doi: 10.1016/s0959-4388(99)80016-6.


Studies dating from the 1950s have documented the impact of early life events on the development of behavioral and endocrine responses to stress. Recent findings suggest that these effects are mediated through changes in mother-offspring interactions and have identified central corticotropin-releasing factor systems as a critical target for the effects of variations in maternal care.

Publication types

  • Review

MeSH terms

  • Animals
  • Corticotropin-Releasing Hormone / physiology
  • Environment*
  • Humans
  • Hypothalamo-Hypophyseal System / physiology
  • Macaca mulatta
  • Maternal Behavior / psychology*
  • Mice
  • Mice, Inbred BALB C
  • Physical Stimulation
  • Pituitary-Adrenal System / physiology
  • Rats
  • Stress, Physiological / etiology*
  • Stress, Physiological / metabolism


  • Corticotropin-Releasing Hormone