Eph receptors and ephrins in neural development

Curr Opin Neurobiol. 1999 Feb;9(1):65-73. doi: 10.1016/s0959-4388(99)80008-7.


Ephrins, ligands for the Eph family of receptor tyrosine kinases, are pivotal players in many developmental phenomena in both the central and peripheral nervous systems. Ephrins appear to act typically, but not exclusively, as repellents throughout development to influence axon pathfinding and topographic mapping, as well as restricting cell migration and intermingling. Recent findings are beginning to characterize the function and signaling of ephrins, as well as major roles for them in other tissues.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Movement
  • Chick Embryo
  • Ephrin-A5
  • Ephrin-B3
  • Membrane Proteins / physiology*
  • Mice
  • Rats
  • Retina / embryology*
  • Retinal Ganglion Cells / physiology*


  • Ephrin-A5
  • Ephrin-B3
  • Membrane Proteins