Specification of dopaminergic and serotonergic neurons in the vertebrate CNS

Curr Opin Neurobiol. 1999 Feb;9(1):26-36. doi: 10.1016/s0959-4388(99)80004-x.


The early specification of dopaminergic and serotonergic neurons during vertebrate CNS development relies on signals produced by a small number of organizing centers. Recent studies have characterized these early organizing centers, the manner in which they may be established, the inductive signals they produce, and candidate signaling systems that control the later development of the dopaminergic system.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, Differentiation
  • Central Nervous System / embryology*
  • Dopamine / genetics*
  • Gene Expression Regulation, Developmental
  • Mesencephalon / embryology
  • Mice
  • Mice, Transgenic
  • Neural Crest / embryology*
  • Neurons
  • Prosencephalon / embryology
  • Rats
  • Rhombencephalon / embryology
  • Serotonin / genetics*
  • Somites
  • Stem Cells
  • Vertebrates


  • Antigens, Differentiation
  • Serotonin
  • Dopamine