Molecular cloning, mapping, and characterization of two novel human genes, ORCTL3 and ORCTL4, bearing homology to organic-cation transporters

Cytogenet Cell Genet. 1998;83(3-4):251-5. doi: 10.1159/000015197.


Through a large-scale sequencing of genomic DNA at 3p22-->p21.3, we have isolated two human genes (ORCTL3 alias OCTL1 and ORCTL4 alias OCTL2) encoding novel members of the family of organic-cation transporter molecules. The predicted proteins revealed the highest similarities to recently- isolated organic-cation transporter proteins, rat OCT-1r, rat NLT and mouse NKT. The transcripts of both genes were expressed ubiquitously in various human tissues, but some tissue-specific transcripts were also observed in kidney, testis, or skeletal muscle. The two genes are clustered within a 52-kb region of genomic DNA and ORCTL4 lies about 27 kb telomeric to ORCTL3 in the genomic DNA sequence in a tail-to-head orientation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Blotting, Northern
  • Carrier Proteins / genetics*
  • Chromosome Mapping
  • Chromosomes, Human, Pair 3 / genetics
  • Cloning, Molecular
  • DNA / chemistry
  • DNA / genetics
  • DNA, Complementary / chemistry
  • DNA, Complementary / genetics
  • DNA, Complementary / isolation & purification
  • Exons
  • Genes / genetics*
  • Humans
  • In Situ Hybridization, Fluorescence
  • Introns
  • Molecular Sequence Data
  • Organic Anion Transporters / genetics*
  • RNA / genetics
  • RNA / metabolism
  • Sequence Alignment
  • Sequence Analysis, DNA
  • Sequence Homology, Amino Acid
  • Tissue Distribution
  • Transcription, Genetic


  • Carrier Proteins
  • DNA, Complementary
  • Organic Anion Transporters
  • SLC22A13 protein, human
  • RNA
  • DNA

Associated data

  • GENBANK/AB010438
  • GENBANK/AB011082
  • GENBANK/AB026898
  • GENBANK/AB026899