Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily

Mech Dev. 1999 Feb;80(2):181-4. doi: 10.1016/s0925-4773(98)00221-4.


Here we report the cloning and expression of murine BMP-10, a novel member of the TGF-beta superfamily. In the mouse embryo, BMP-10 expression begins at 9.0 d.p.c. and is restricted to the developing heart. Initially, BMP-10 expression localizes to the trabeculated part of the common ventricular chamber and to the bulbus cordis region. After 12.5 d.p.c., additional BMP-10 expression is seen in the atrial wall. The data presented here suggest that BMP-10 plays an important role in trabeculation of the embryonic heart.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Bone Morphogenetic Proteins / biosynthesis*
  • Bone Morphogenetic Proteins / genetics
  • Embryonic and Fetal Development / genetics
  • Fetal Heart / metabolism*
  • Fetal Proteins / biosynthesis*
  • Fetal Proteins / genetics
  • Gene Expression Regulation, Developmental*
  • Genes*
  • In Situ Hybridization
  • Mice
  • Molecular Sequence Data
  • Multigene Family*
  • Muscle Proteins / biosynthesis*
  • Muscle Proteins / genetics
  • Myocardium / metabolism*
  • Polymerase Chain Reaction
  • Sequence Alignment
  • Transforming Growth Factor beta / genetics


  • Bmp10 protein, mouse
  • Bone Morphogenetic Proteins
  • Fetal Proteins
  • Muscle Proteins
  • Transforming Growth Factor beta

Associated data

  • GENBANK/AF101033