Chemokines and Chemokine Receptors: Biology and Clinical Relevance in Inflammation and AIDS

Annu Rev Med. 1999;50:425-40. doi: 10.1146/annurev.med.50.1.425.

Abstract

Chemokines constitute a large family of chemotactic cytokines that act at G protein-coupled receptors to regulate diverse biological processes, including leukocyte trafficking, angiogenesis, hematopoiesis, and organogenesis. They are believed to be both beneficial in host defense against infectious agents and harmful in diseases marked by pathologic inflammation; however, actual clinical roles in these areas have not yet been established. Recently, unexpected ways have been discovered in which medically important pathogens, including HIV-1, exploit or subvert the chemokine system. These and other recent results suggest that targeting specific chemokines and chemokine receptors may have therapeutic utility in both inflammation and infectious disease.

Publication types

  • Review

MeSH terms

  • Acquired Immunodeficiency Syndrome / immunology*
  • Acquired Immunodeficiency Syndrome / therapy
  • Chemokines / physiology*
  • Chemokines / therapeutic use
  • Chemotaxis, Leukocyte / physiology
  • Embryonic and Fetal Development / physiology
  • GTP-Binding Proteins / physiology
  • HIV-1 / immunology
  • Hematopoiesis / physiology
  • Humans
  • Inflammation / immunology*
  • Inflammation / therapy
  • Neovascularization, Physiologic / physiology
  • Receptors, Chemokine / physiology*

Substances

  • Chemokines
  • Receptors, Chemokine
  • GTP-Binding Proteins