Loss of bone mineral in patients with cachexia due to chronic heart failure

Am J Cardiol. 1999 Feb 15;83(4):612-5, A10. doi: 10.1016/s0002-9149(98)00927-8.


We studied body composition and cytokine levels in 58 patients with heart failure and 16 control patients using dual-energy x-ray absorptiometry. Bone mineral content and density, and lean and fat tissue content, were reduced in cachectic compared with noncachectic patients and control subjects, with negative relations between indexes of bone composition and tumor necrosis factor and tumor necrosis factor receptor 1.

MeSH terms

  • Absorptiometry, Photon
  • Body Composition*
  • Bone Density*
  • Cachexia / etiology
  • Cachexia / physiopathology*
  • Heart Failure / complications
  • Heart Failure / physiopathology*
  • Humans
  • Interleukin-6 / blood
  • Middle Aged
  • Prospective Studies
  • Receptors, Tumor Necrosis Factor / blood
  • Tumor Necrosis Factor-alpha / analysis


  • Interleukin-6
  • Receptors, Tumor Necrosis Factor
  • Tumor Necrosis Factor-alpha