How Taxol stabilises microtubule structure

Chem Biol. 1999 Mar;6(3):R65-9. doi: 10.1016/s1074-5521(99)89002-4.


The structure of tubulin shows paclitaxel (Taxol(R)) binding to a pocket in beta tubulin on the microtubule's inner surface, which counteracts the effects of GTP hydrolysis occurring on the other side of the monomer.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Humans
  • Microtubules / drug effects*
  • Microtubules / enzymology
  • Microtubules / ultrastructure
  • Molecular Sequence Data
  • Paclitaxel / pharmacology*
  • Protein Conformation


  • Antineoplastic Agents, Phytogenic
  • Paclitaxel