NTRK1 re-arrangement in papillary thyroid carcinomas of children after the Chernobyl reactor accident

Int J Cancer. 1999 Mar 15;80(6):842-7. doi: 10.1002/(sici)1097-0215(19990315)80:6<842::aid-ijc7>3.0.co;2-z.


The prevalence of NTRK1 re-arrangement was determined in papillary thyroid carcinomas (PTCs) of children from Belarus who had been exposed to radioactive iodine after the Chernobyl reactor accident; 81 tumors were included, all of which were devoid of RET re-arrangement as analyzed in a current study on genomic alterations in PTC. Oncogenic fusion of the NTRK1 tyrosine kinase domain with the amino-terminal part of the tropomyosin gene (TPM3/NTRK1, trk) was observed in 5 tumors. A single tumor exhibited a TPR/NTRK1 fusion (TRK-T2). Reciprocal NTRK1/TPM3 transcripts were found in 4 of 5 tumors with TPM3/NTRK1 re-arrangement, indicating an intra-chromosomal balanced reciprocal inversion. No phenotypic differences from other post-Chernobyl childhood PTCs were detected. As compared with the high prevalence of RET re-arrangements reported for thyroid carcinomas of children after the Chernobyl reactor accident, NTRK1 re-arrangements appear rare. Our results confirm that activation of receptor tyrosine kinase genes plays the predominant role in post-Chernobyl childhood thyroid carcinogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Carcinoma, Papillary / epidemiology
  • Carcinoma, Papillary / etiology
  • Carcinoma, Papillary / genetics*
  • Carcinoma, Papillary / pathology
  • Child
  • Drosophila Proteins*
  • Female
  • Humans
  • Male
  • Neoplasm Proteins / genetics*
  • Neoplasms, Radiation-Induced / epidemiology
  • Neoplasms, Radiation-Induced / genetics*
  • Oncogene Proteins, Fusion / genetics
  • Power Plants*
  • Proto-Oncogene Proteins / genetics*
  • Proto-Oncogene Proteins c-ret
  • RNA, Messenger / analysis
  • RNA, Neoplasm / analysis
  • Radioactive Hazard Release*
  • Receptor Protein-Tyrosine Kinases / genetics*
  • Receptor, trkA
  • Receptors, Nerve Growth Factor / genetics*
  • Thyroid Neoplasms / epidemiology
  • Thyroid Neoplasms / etiology
  • Thyroid Neoplasms / genetics*
  • Thyroid Neoplasms / pathology
  • Ukraine / epidemiology


  • Drosophila Proteins
  • Neoplasm Proteins
  • Oncogene Proteins, Fusion
  • Proto-Oncogene Proteins
  • RNA, Messenger
  • RNA, Neoplasm
  • Receptors, Nerve Growth Factor
  • Proto-Oncogene Proteins c-ret
  • Receptor Protein-Tyrosine Kinases
  • Receptor, trkA
  • Ret protein, Drosophila