Chromosomal clues to the development of prostate tumors

Prostate. 1999 Mar 1;38(4):303-12. doi: 10.1002/(sici)1097-0045(19990301)38:4<303::aid-pros6>;2-e.


Background: Cytogenetic, molecular cytogenetic, and molecular studies of prostate cancer have revealed an enormous amount of data regarding chromosomal loci that are aberrant in prostate tumors.

Methods: These data have been compared and condensed in this review to determine which chromosomes and chromosome sites have been most frequently reported.

Results: Loss of the Y chromosome, gain of 7, 8, and X, and interstitial deletions on 6q, 7q, 8p, 10q, 13q, 16q, 17q, and 18q are the most prevalent.

Conclusions: A potential model for genetic control of tumor progression is presented, as are data regarding the evaluation of a new series of tumors.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Chromosome Aberrations / genetics*
  • Humans
  • Karyotyping
  • Male
  • Prostatic Neoplasms / genetics*