Background: Cytogenetic, molecular cytogenetic, and molecular studies of prostate cancer have revealed an enormous amount of data regarding chromosomal loci that are aberrant in prostate tumors.
Methods: These data have been compared and condensed in this review to determine which chromosomes and chromosome sites have been most frequently reported.
Results: Loss of the Y chromosome, gain of 7, 8, and X, and interstitial deletions on 6q, 7q, 8p, 10q, 13q, 16q, 17q, and 18q are the most prevalent.
Conclusions: A potential model for genetic control of tumor progression is presented, as are data regarding the evaluation of a new series of tumors.