Methimazole embryopathy: delineation of the phenotype

Am J Med Genet. 1999 Mar 5;83(1):43-6.

Abstract

We report on a further case of congenital anomalies in a child exposed to methimazole during the first trimester of pregnancy (from first to seventh gestational week), and define a specific malformation pattern related to prenatal methimazole exposure and consisting of choanal and esophageal atresia, scalp defects, minor facial anomalies and psychomotor delay.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Abnormalities, Drug-Induced / genetics*
  • Adult
  • Antithyroid Agents / toxicity*
  • Child, Preschool
  • Choanal Atresia / chemically induced
  • Esophageal Atresia / chemically induced
  • Female
  • Graves Disease / drug therapy
  • Humans
  • Male
  • Maternal-Fetal Exchange
  • Methimazole / toxicity*
  • Phenotype
  • Pregnancy
  • Pregnancy Trimester, First
  • Teratogens*

Substances

  • Antithyroid Agents
  • Teratogens
  • Methimazole