Apolipoprotein E genotype does not affect the age of onset of dementia in families with defined tau mutations

Neurosci Lett. 1999 Feb 5;260(3):193-5. doi: 10.1016/s0304-3940(98)00931-8.


We have assessed whether apolipoprotein E (ApoE) genotype influences the age of onset of dementia in a series of families with frontal temporal dementia with defined mutations in the tau gene. In contrast to the situation in Alzheimer's disease (AD), we could find no evidence that the age of onset of disease was influenced by the ApoE genotype.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Age of Onset
  • Aged
  • Apolipoproteins E / genetics*
  • Chromosomes, Human, Pair 17 / genetics
  • Dementia / genetics*
  • Dementia / psychology
  • Genotype
  • Humans
  • Middle Aged
  • Mutation, Missense / physiology
  • Parkinson Disease / genetics
  • tau Proteins / genetics*


  • Apolipoproteins E
  • tau Proteins