Beta-glucuronidase-inhibitory activity and hepatoprotective effect of Ganoderma lucidum

Biol Pharm Bull. 1999 Feb;22(2):162-4. doi: 10.1248/bpb.22.162.


To prove the relationship between the fluctuation in serum beta-glucuronidase level and hepatotoxicity, an inhibitor of beta-glucuronidase from G. lucidum was isolated and its hepatoprotective activity was investigated. The ether fraction of G. lucidum, which had potent beta-glucuronidase-inhibitory activity, protected against CCl4-induced liver injury. From this ether fraction, ganoderenic acid A, was isolated as the potent inhibitor of beta-glucuronidase. It had a potent hepatoprotective effect against CCl4-induced liver injury. These results suggest that the beta-glucuronidase seems to be closely related to liver injury, which could be prevented by beta-glucuronidase inhibitors.

MeSH terms

  • Animals
  • Carbon Tetrachloride Poisoning / prevention & control
  • Chemical and Drug Induced Liver Injury / prevention & control*
  • Cholestanes / chemistry
  • Cholestanes / isolation & purification
  • Cholestanes / pharmacology*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology*
  • Glucuronidase / antagonists & inhibitors*
  • Liver / drug effects*
  • Male
  • Polyporaceae / chemistry*
  • Rats
  • Rats, Wistar
  • Spectrum Analysis


  • Cholestanes
  • Enzyme Inhibitors
  • ganoderenic acid A
  • Glucuronidase