Postnatal development of dopamine D1-like receptors in rat cortical and striatolimbic brain regions: An autoradiographic study

Dev Neurosci. 1999;21(1):43-9. doi: 10.1159/000017365.


Postnatal development of dopamine D1-like (D1/D5) receptors in rat caudate-putamen (CPu), nucleus accumbens (NAc), hippocampus, frontal and entorhinal cerebral cortex was assessed between postnatal days (PD) 7-60 by in vitro receptor autoradiography. Density of [3H]SCH-23390 binding to D1-like receptors increased from PD-7 to a peak at PD-28 in CPu (11-fold) and NAc (23-fold), then declined by 20-40% in both regions over PD-35-60, to adult levels. In hippocampus, frontal and entorhinal cortex, D1-like receptors increased by lesser amounts (3- to 4-fold) from PD-7 to stable, maximal adult levels at PD-60. Evidently, excess D1-like receptors were eliminated during maturation of CPu and NAc, but not in the other forebrain regions. Postnatal D1-like receptor development in rat forebrain paralleled that of D2- and D4-like receptors in the same regions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aging
  • Animals
  • Autoradiography
  • Cerebral Cortex / growth & development
  • Cerebral Cortex / metabolism*
  • Corpus Striatum / growth & development
  • Corpus Striatum / metabolism*
  • Entorhinal Cortex / growth & development
  • Entorhinal Cortex / metabolism
  • Hippocampus / growth & development
  • Hippocampus / metabolism
  • Limbic System / growth & development
  • Limbic System / metabolism*
  • Male
  • Nucleus Accumbens / growth & development
  • Nucleus Accumbens / metabolism
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Dopamine D1 / metabolism*


  • Receptors, Dopamine D1