Contribution of interleukin 1beta and KM loci to alopecia areata

Hum Hered. 1999 Mar;49(2):85-9. doi: 10.1159/000022850.

Abstract

Alopecia areata is a common skin disease in which proinflammatory cytokines such as IL-1beta may play a pathogenic role. In this study, we examined the distribution of genotypes of an IL-1beta single base change polymorphism at position +3953 in patients with alopecia areata. The distribution of immunoglobulin kappa light chain (KM) genotypes was similarly examined. The data obtained showed that the IL-1beta and KM loci act cooperatively to significantly increase susceptibility to alopecia areata.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Alopecia Areata / genetics*
  • Child
  • Chromosomes, Human, Pair 2 / genetics
  • Genotype
  • Heterozygote
  • Homozygote
  • Humans
  • Immunoglobulin kappa-Chains / genetics*
  • Interleukin-1 / genetics*
  • Polymorphism, Genetic

Substances

  • Immunoglobulin kappa-Chains
  • Interleukin-1