Creatine monohydrate increases strength in patients with neuromuscular disease

Neurology. 1999 Mar 10;52(4):854-7. doi: 10.1212/wnl.52.4.854.


Creatine monohydrate has been shown to increase strength in studies of young healthy subjects and in a few studies with patients. Creatine monohydrate (10 g daily for 5 days to 5 g daily for 5 days) was administered to patients with neuromuscular disease in a pilot study (Study 1; n = 81), followed by a single-blinded study (Study 2; n = 21). Body weight, handgrip, dorsiflexion, and knee extensor strength were measured before and after treatment. Creatine administration increased all measured indices in both studies. Short-term creatine monohydrate increased high-intensity strength significantly in patients with neuromuscular disease.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Child
  • Creatine / adverse effects
  • Creatine / therapeutic use*
  • Humans
  • Middle Aged
  • Muscles / drug effects
  • Neuromuscular Diseases / drug therapy*
  • Organ Size / drug effects
  • Single-Blind Method
  • Time Factors


  • Creatine