Do hallucinogens cause residual neuropsychological toxicity?

Drug Alcohol Depend. 1999 Feb 1;53(3):247-56. doi: 10.1016/s0376-8716(98)00129-x.


We collected and reviewed studies in which neuropsychological tests were administered to users of LSD or other hallucinogens. Interpretation of the studies is limited by various confounding variables, such as subjects' premorbid cognitive and personality function and prior use of other substances. At present, the literature tentatively suggests that there are few, if any, long-term neuropsychological deficits attributable to hallucinogen use. To better resolve this issue, however, it will be important to study larger samples of chronic, frequent hallucinogen users who have not often used other types of drugs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Chronic Disease
  • Cognition Disorders / chemically induced*
  • Cognition Disorders / diagnosis*
  • Female
  • Hallucinogens / adverse effects*
  • Humans
  • Lysergic Acid Diethylamide / adverse effects*
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Personality Disorders / chemically induced*
  • Personality Disorders / diagnosis*
  • Serotonin / metabolism
  • Severity of Illness Index
  • Substance-Related Disorders / diagnosis
  • Time Factors


  • Hallucinogens
  • Serotonin
  • Lysergic Acid Diethylamide