Involvement of nucleotide-excision repair in msh2 pms1-independent mismatch repair

Nat Genet. 1999 Mar;21(3):314-7. doi: 10.1038/6838.


Nucleotide-excision repair (NER) and mismatch repair (MMR) are prominent examples of highly conserved DNA repair systems which recognize and replace damaged and/or mispaired nucleotides in DNA. In humans, inheritable defects in components of the NER system are associated with severe diseases such as xeroderma pigmentosum (XP) and Cockayne syndrome (CS), whereas inactivation of MMR is accompanied by predisposition to certain types of cancer. In Schizosaccharomyces pombe, the msh2- and pms1-dependent long-patch MMR system efficiently corrects small insertion/deletion loops and all base-base mismatches, except C/C. Up to 70% of C/C mismatches generated in recombination intermediates, and to a lesser extent also other base-base mismatches, are thought to undergo correction by a minor, short-patch excision repair system. We identify here the NER genes rhpl4, swi10 and rad16 as components of this repair pathway and show that they act independently of msh2 and pms1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine Triphosphatases*
  • Base Pair Mismatch*
  • Carrier Proteins*
  • Crosses, Genetic
  • DNA Repair / physiology*
  • DNA-Binding Proteins / genetics*
  • Fungal Proteins / genetics*
  • Mitosis
  • Molecular Sequence Data
  • MutS Homolog 2 Protein
  • Mutation
  • Recombination, Genetic
  • Saccharomyces cerevisiae Proteins*
  • Schizosaccharomyces / genetics*
  • Schizosaccharomyces / physiology
  • Schizosaccharomyces pombe Proteins*


  • Carrier Proteins
  • DNA-Binding Proteins
  • Fungal Proteins
  • SWI10 protein, S pombe
  • Saccharomyces cerevisiae Proteins
  • Schizosaccharomyces pombe Proteins
  • Adenosine Triphosphatases
  • MSH2 protein, S cerevisiae
  • MutS Homolog 2 Protein
  • RAD16 protein, S cerevisiae
  • msh2 protein, S pombe

Associated data

  • GENBANK/AL023587