Macrophages in host defense against Histoplasma capsulatum

Trends Microbiol. 1999 Feb;7(2):67-71. doi: 10.1016/s0966-842x(98)01431-0.

Abstract

Macrophages function in both innate and cell-mediated immunity in host defense against pathogenic fungi. They initially serve as a protected environment in which the primary fungal pathogen Histoplasma capsulatum multiplies and disseminates from the lung to other organs. Upon induction of cell-mediated immunity, cytokines activate macrophages to destroy the yeasts and thus remove them from the host.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Histoplasma / immunology*
  • Histoplasma / physiology
  • Histoplasmosis / immunology*
  • Histoplasmosis / microbiology
  • Humans
  • Macrophage Activation
  • Macrophages / immunology*
  • Macrophages / microbiology
  • Mice
  • Mycobacterium / immunology
  • Mycobacterium / physiology
  • Phagocytosis
  • Phagosomes / physiology
  • Respiratory Burst