Prevalence of the metabolic syndrome in drug-treated hypertensive patients and control subjects

J Intern Med. 1999 Feb;245(2):163-74. doi: 10.1046/j.1365-2796.1999.00429.x.


Objectives: To determine the prevalence of the metabolic abnormalities associated with hypertension and to define the predictors of the metabolic syndrome by different definitions in random population-based samples.

Design: A cross-sectional epidemiological study of hypertensive patients and controls.

Setting: The participating study subjects visited the research laboratory of the Department of Internal Medicine, University of Oulu, Oulu, Finland.

Subjects: Six hundred treated male and female hypertensives aged 40-59 years and 600 age- and sex-matched controls were randomly selected by age stratification from population registers.

Main outcome measures: A wide range of laboratory analyses were conducted. After fasting blood had been drawn, the subjects were given a 75 g glucose load except previously known insulin-treated diabetics. Both 1 h and 2 h glucose and insulin concentrations were determined. During the same visit, a standardized health questionnaire covering the past medical history, current and former medication use, physical activity, smoking habits, alcohol consumption and family history was completed. Ten different definitions of the metabolic syndrome were applied to achieve a wide perspective of the prevalence of the different combinations.

Results: The prevalence of the metabolic syndrome in different samples varied depending on the definition from 0.8 to 35.3%, being lowest in the control men and women and highest in the hypertensive men. Three-quarters of a random, middle-aged, urban population show at least one cardiovascular risk factor and 91.3% of all the hypertensive subjects show at least one cardiovascular risk factor in addition to hypertension itself. The independent predictors of the metabolic syndrome were waist circumference, uric acid, total cholesterol and gamma-glutamyl transpeptidase in logistic analysis after adjustment for age, measure of obesity and gender.

Conclusions: This cross-sectional, epidemiological study shows that the magnitude of the prevalence rates of the metabolic syndrome is at the same level in various populations, being less than one-third in population-based samples in spite of the different definitions. The cluster of several cardiovascular risk factors, especially in the hypertensives, leads to an increased relative risk of cardiovascular diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antihypertensive Agents / therapeutic use*
  • Blood Pressure Determination
  • Case-Control Studies
  • Cross-Sectional Studies
  • Female
  • Finland / epidemiology
  • Humans
  • Hyperinsulinism / epidemiology
  • Hyperlipidemias / epidemiology
  • Hypertension / blood
  • Hypertension / drug therapy*
  • Hypertension / etiology*
  • Logistic Models
  • Male
  • Metabolic Diseases / blood
  • Metabolic Diseases / complications
  • Metabolic Diseases / epidemiology*
  • Middle Aged
  • Prevalence
  • Risk Factors
  • Syndrome


  • Antihypertensive Agents