Neuroprotective effect of rasagiline, a selective monoamine oxidase-B inhibitor, against closed head injury in the mouse

Eur J Pharmacol. 1999 Feb 5;366(2-3):127-35. doi: 10.1016/s0014-2999(98)00929-7.

Abstract

The potential neuroprotective effects of rasagiline, N-propargyl-1R-aminoindan, a selective monoamine oxidase-B inhibitor and its inactive enantiomer TVP 1022, N-propargyl-1S-aminoindan were assessed against the sequelae of closed head injury in the mouse. Injury was induced in the left hemisphere under ether anaesthesia. Rasagiline (0.2 and 1 mg/kg) or TVP1022 (1 and 2 mg/kg) injected 5 min after injury accelerated the recovery of motor function and spatial memory and reduced the cerebral oedema by about 40-50%, (P < 0.01). The neuroprotective effects on motor function and spatial memory, but not on cerebral oedema, were prevented by scopolamine (0.2 mg/kg). Daily injection of rasagiline (1 mg/kg) from day 3 after injury accelerated the recovery of spatial memory but not motor function.

Conclusions: Early administration of rasagiline or TVP1022 can reduce the immediate sequelae of brain injury. The mechanism of action does not appear to involve monoamine oxidase-B inhibition but could be mediated by the maintenance of cholinergic transmission in brain neurons.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Blood-Brain Barrier / drug effects
  • Brain / drug effects
  • Brain / enzymology
  • Brain Edema / pathology
  • Brain Edema / physiopathology
  • Brain Edema / prevention & control
  • Head Injuries, Closed / pathology
  • Head Injuries, Closed / physiopathology
  • Head Injuries, Closed / prevention & control*
  • Indans / pharmacology*
  • Indans / therapeutic use
  • Male
  • Maze Learning / drug effects
  • Memory Disorders / drug therapy
  • Memory Disorders / physiopathology
  • Memory, Short-Term / drug effects
  • Mice
  • Monoamine Oxidase / drug effects
  • Monoamine Oxidase / metabolism
  • Monoamine Oxidase Inhibitors / pharmacology*
  • Monoamine Oxidase Inhibitors / therapeutic use
  • Neuropsychological Tests
  • Psychomotor Disorders / drug therapy
  • Psychomotor Disorders / physiopathology
  • Psychomotor Performance / drug effects

Substances

  • Indans
  • Monoamine Oxidase Inhibitors
  • rasagiline
  • Monoamine Oxidase