Efficacy of lamotrigine in refractory neonatal seizures

Pediatr Neurol. 1999 Feb;20(2):161-3. doi: 10.1016/s0887-8994(98)00125-8.


A newborn infant with seizures of unknown etiology that were refractory to treatment with phenobarbitone, phenytoin, midazolam, clonazepam, and vigabatrin is reported. The introduction of the new antiepileptic drug lamotrigine was followed by rapid and sustained control of the seizures.

Publication types

  • Case Reports

MeSH terms

  • Anticonvulsants / therapeutic use*
  • Drug Resistance
  • Electroencephalography
  • Female
  • Humans
  • Infant, Newborn
  • Lamotrigine
  • Seizures / drug therapy*
  • Treatment Outcome
  • Triazines / therapeutic use*


  • Anticonvulsants
  • Triazines
  • Lamotrigine