HLA haplotypes and microsatellite polymorphisms in and around the major histocompatibility complex region in a Native American population with a high prevalence of scleroderma (systemic sclerosis)

Tissue Antigens. 1999 Jan;53(1):74-80. doi: 10.1034/j.1399-0039.1999.530108.x.

Abstract

Choctaw Native Americans in southeastern Oklahoma have the highest prevalence of scleroderma or systemic sclerosis yet found (469/100,000). An Amerindian HLA DR2 haplotype (DRB1*1602) was significantly associated with scleroderma in this population in a previous study. It is not known, however, if other disease genes are linked to this HLA haplotype. The regions flanking the HLA loci were studied with polymorphic microsatellite markers. An extended HLA DR2 (DRB1*1602, DQA1*0501, DQB1*0301, DPB1*1301) haplotype that includes the class I and III regions was identified which was significantly associated with scleroderma in the Oklahoma Choctaw. No other significant associations with microsatellite marker alleles immediately flanking the HLA region were found.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Autoimmune Diseases / epidemiology
  • Autoimmune Diseases / ethnology*
  • Autoimmune Diseases / genetics
  • Genetic Predisposition to Disease
  • Genotype
  • HLA Antigens / genetics*
  • Haplotypes / genetics
  • Humans
  • Indians, North American / genetics*
  • Linkage Disequilibrium
  • Major Histocompatibility Complex / genetics*
  • Microsatellite Repeats*
  • Oklahoma / epidemiology
  • Pedigree
  • Polymerase Chain Reaction
  • Prevalence
  • Scleroderma, Systemic / epidemiology
  • Scleroderma, Systemic / ethnology*
  • Scleroderma, Systemic / genetics

Substances

  • HLA Antigens