Use of disodium pamidronate in children with hypercalcemia awaiting liver transplantation

Pediatr Transplant. 1998 May;2(2):157-9.


We report four children with advanced liver disease awaiting liver transplantation who developed moderately severe hypercalcemia (range: 1.65-2.40 mmol/L) while receiving total parenteral nutrition. Hypercalcemia had been unresponsive to cessation of calcium intake and therapy with loop diuretics and calcitonin. One or two intravenous doses of disodium pamidronate (35-50 mg/m2) resulted in normalization of plasma calcium concentration within 2-4 d in all four children. Pamidronate may be useful for children with hypercalcemia associated with liver disease.

MeSH terms

  • Child
  • Child, Preschool
  • Diphosphonates / administration & dosage
  • Diphosphonates / therapeutic use*
  • Drug Administration Schedule
  • Female
  • Humans
  • Hypercalcemia / drug therapy*
  • Hypercalcemia / etiology
  • Infant
  • Liver Diseases / complications*
  • Liver Transplantation*
  • Male
  • Osteoclasts / drug effects
  • Pamidronate
  • Parenteral Nutrition, Total / adverse effects


  • Diphosphonates
  • Pamidronate