Blockade of CD40L/CD40 costimulatory pathway in a DST presensitization model of islet allograft leads to a state of Allo-Ag specific tolerance and permits subsequent engraftment of donor strain islet or heart allografts

Transplant Proc. 1999 Feb-Mar;31(1-2):627-8. doi: 10.1016/s0041-1345(98)01588-7.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Monoclonal / therapeutic use
  • Blood Transfusion*
  • CD40 Antigens / immunology*
  • CD40 Ligand
  • Cricetinae
  • Graft Survival
  • Heart Transplantation / immunology*
  • Immune Tolerance
  • Immunoglobulins, Intravenous / therapeutic use
  • Immunosuppression Therapy / methods*
  • Islets of Langerhans Transplantation / immunology*
  • Isoantigens / immunology*
  • Membrane Glycoproteins / antagonists & inhibitors
  • Membrane Glycoproteins / immunology*
  • Mice
  • Mice, Inbred DBA
  • Mice, Inbred Strains
  • Transplantation, Homologous

Substances

  • Antibodies, Monoclonal
  • CD40 Antigens
  • Immunoglobulins, Intravenous
  • Isoantigens
  • Membrane Glycoproteins
  • CD40 Ligand