Isolation and mapping of a polymorphic CA repeat sequence at the human VRK1 locus

J Sugimoto; T Yamauchi; T Hatakeyama; M Isobe

doi:10.1007/s100380050127

Isolation and mapping of a polymorphic CA repeat sequence at the human VRK1 locus

J Hum Genet. 1999;44(2):133-4. doi: 10.1007/s100380050127.

Authors

J Sugimoto¹, T Yamauchi, T Hatakeyama, M Isobe

Affiliation

¹ Department of Materials and Biosystem Engineering, Faculty of Engineering, Toyama University, Japan.

PMID: 10083742
DOI: 10.1007/s100380050127

Abstract

VRK1 is a novel human putative serine/threonine kinase, and is located on chromosome 14 at band q32 where an autosomal recessive congenital microphthalmia (CMIC) is mapped. We isolated a polymorphic dinucleotide CA repeat marker from a genomic clone containing the human VRK1 gene. This polymorphism will be useful in genetic studies of disorders localized at the 14q32 region, such as CMIC.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 14
DNA Primers
Dinucleotide Repeats*
Eye Abnormalities / genetics
Humans
Intracellular Signaling Peptides and Proteins
Polymerase Chain Reaction
Polymorphism, Genetic*
Protein Serine-Threonine Kinases / genetics*
Proteins*
Viral Proteins / genetics*

Substances

DNA Primers
Intracellular Signaling Peptides and Proteins
Proteins
Viral Proteins
Protein Serine-Threonine Kinases
VRK1 protein, human

Associated data

GENBANK/AB025785