Polymyalgia, hypersensitivity pneumonitis and other reactions in patients receiving HMG-CoA reductase inhibitors: a report of ten cases

Chest. 1999 Mar;115(3):886-9. doi: 10.1378/chest.115.3.886.


Ten patients who take hydroxy-methylglutaryl coenzyme A reductase inhibitors, or statin medications, and experience adverse reactions are described. All patients experienced various manifestations of hypersensitivity while receiving the drugs. One patient is described with hypersensitivity pneumonitis, which was graphically demonstrated by both high resolution computerized axial tomography and open lung biopsy.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alveolitis, Extrinsic Allergic / chemically induced*
  • Female
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / adverse effects*
  • Lovastatin / adverse effects*
  • Male
  • Middle Aged
  • Polymyalgia Rheumatica / chemically induced*
  • Pravastatin / adverse effects*
  • Ventricular Dysfunction, Left / chemically induced


  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Lovastatin
  • Pravastatin