Independent influence of age on basal insulin secretion in nondiabetic humans. European Group for the Study of Insulin Resistance

J Clin Endocrinol Metab. 1999 Mar;84(3):863-8. doi: 10.1210/jcem.84.3.5542.


Glucose tolerance deteriorates with aging. To test whether age per se impairs basal beta-cell function, we analyzed retrospective clamp data from a large group (n = 957) of nondiabetic Europeans over the 18-85 yr age range (the European Group for the Study of Insulin Resistance database). In this cohort, the fasting posthepatic insulin delivery rate [IDR, obtained as the product of clamp-derived posthepatic insulin MCR and fasting plasma insulin concentration] was 8.9 (6.6) mU/min (median and interquartile range), and it gradually increased with age. In univariate association, IDR was positively related to body mass index (P < 0.0001), fasting plasma glucose (P < 0.01), and waist-to-hip ratio (P < 0.001), and negatively related to insulin sensitivity (P < 0.0001). After controlling for these factors in a multivariate model, IDR declined significantly with age (P < 0.0001). This intrinsic effect of age on IDR was similar in men and women, and it averaged 25% between 18-85 yr. In the same statistical model, insulin MCR (but not fasting plasma insulin concentration) showed a significant (P < 0.0001) inverse relation to age. We conclude that, in nondiabetic Caucasian subjects of either sex, senescence per se is associated with a progressive decline in both insulin clearance and basal insulin release.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging / metabolism*
  • Biological Availability
  • Blood Glucose / analysis
  • Body Constitution
  • Body Mass Index
  • Cohort Studies
  • Female
  • Humans
  • Insulin / metabolism*
  • Insulin / pharmacokinetics
  • Insulin Resistance
  • Insulin Secretion
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Reference Values


  • Blood Glucose
  • Insulin