Cyclosporine-induced white and grey matter central nervous system lesions in a pediatric renal transplant patient

Pediatr Transplant. 1998 Feb;2(1):45-50.


Major neurologic complications secondary to cyclosporine are well documented and are known to include confusion, cortical blindness, seizure, spasticity, paresis, ataxia and coma. Most previous reports attribute these to white matter central nervous system (CNS) lesions or white/grey matter border lesions. Many predisposing factors have been identified, including: elevated levels of cyclosporine, hypomagnesemia, hypocholesterolemia, aluminium toxicity, high dose steroids, hypertension and infection. However CNS events attributed to cyclosporine have been reported without any of these risk factors. We report a case of a child developing multiple white and grey matter thalamic and cortical lesions along with acute neurologic deterioration, and then review cyclosporine mediated CNS injury, including the roles of P-glycoprotein and cyclophilin.

Publication types

  • Case Reports

MeSH terms

  • Biopsy
  • Brain Diseases / chemically induced*
  • Brain Diseases / diagnosis
  • Cerebral Cortex / drug effects*
  • Cerebral Cortex / pathology
  • Child, Preschool
  • Cyclosporine / adverse effects*
  • Follow-Up Studies
  • Glucocorticoids / therapeutic use
  • Graft Rejection / drug therapy
  • Humans
  • Immunosuppressive Agents / adverse effects*
  • Kidney Transplantation*
  • Magnetic Resonance Imaging
  • Male
  • Thalamus / drug effects*
  • Thalamus / pathology
  • Tomography, X-Ray Computed


  • Glucocorticoids
  • Immunosuppressive Agents
  • Cyclosporine