The increased incidence of multiple gestations has raised many questions regarding the differences in the care of twins versus singletons. The concept of co-bedding twins in the neonatal intensive care unit (NICU) has drawn increased attention in recent years. A NICU in a children's hospital in the Mid-Atlantic region of the United States explored the benefits and risks to this practice, and developed a guideline for double bunking twins. The guideline provides health care professionals with a safe and efficient means to arrange a physical environment that will simulate the environment many parents will use at home. Research is needed to determine the potential physical, psychologic, or psychosocial benefits of co-bedding multiple-gestation infants.