Bi-cycling the Furin Pathway: From TGN Localization to Pathogen Activation and Embryogenesis

Trends Cell Biol. 1999 Jan;9(1):28-35. doi: 10.1016/s0962-8924(98)01382-8.


Furin is a secretory pathway endoprotease that catalyses the maturation of a strikingly diverse group of proprotein substrates, ranging from growth factors and receptors to pathogen proteins, in multiple compartments within the trans-Golgi network (TGN)/endosomal system. This review focuses on recent developments in the biochemistry and cell biology of the endoprotease, including the mechanism of TGN localization, phosphorylation-dependent regulation of protein traffic, and novel insights into early embryogenesis, extracellular matrix formation and pathogen virulence.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Binding Sites
  • Extracellular Matrix / metabolism
  • Furin
  • Golgi Apparatus / metabolism*
  • Hydrogen-Ion Concentration
  • Molecular Sequence Data
  • Subtilisins / metabolism*
  • Virulence


  • Subtilisins
  • Furin