Case study: carbamazepine treatment of juvenile-onset bipolar disorder

J Am Acad Child Adolesc Psychiatry. 1999 Mar;38(3):335-8. doi: 10.1097/00004583-199903000-00022.


The literature devoted to juvenile-onset bipolar disorder has rapidly expanded in the past 5 years with an emphasis on new concepts of prevalence and comorbid conditions. In the process of enlarging the knowledge base about the phenomenology of juvenile-onset bipolar disorder, this new literature has generated considerable controversy but has provided little information about pharmacotherapy. In the following case series, carbamazepine appeared to be a safe and effective treatment for juvenile-onset bipolar disorder. Controlled studies are necessary before any definitive conclusions can be reached about the efficacy of carbamazepine in the treatment of this form of bipolar disorder.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adolescent
  • Antimanic Agents / administration & dosage*
  • Antimanic Agents / adverse effects
  • Bipolar Disorder / diagnosis
  • Bipolar Disorder / drug therapy*
  • Bipolar Disorder / genetics
  • Carbamazepine / administration & dosage*
  • Carbamazepine / adverse effects
  • Child
  • Female
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Male
  • Treatment Outcome


  • Antimanic Agents
  • Carbamazepine