Moonlighting proteins

Trends Biochem Sci. 1999 Jan;24(1):8-11. doi: 10.1016/s0968-0004(98)01335-8.


The idea of one gene--one protein--one function has become too simple because increasing numbers of proteins are found to have two or more different functions. The multiple functions of such moonlighting proteins add another dimension to cellular complexity and benefit cells in several ways. However, cells have had to develop sophisticated mechanisms for switching between the distinct functions of these proteins.

Publication types

  • Review

MeSH terms

  • Animals
  • Binding Sites
  • Gene Expression
  • Humans
  • Macromolecular Substances
  • Models, Biological
  • Protein Binding
  • Protein Conformation
  • Proteins / genetics*
  • Proteins / physiology*


  • Macromolecular Substances
  • Proteins