Dealing with energy demand: the AMP-activated protein kinase

Trends Biochem Sci. 1999 Jan;24(1):22-5. doi: 10.1016/s0968-0004(98)01340-1.

Abstract

The AMP-activated protein kinase (AMPK) is a member of a metabolite-sensing protein kinase family that is found in all eukaryotes. AMPK activity is regulated by vigorous exercise, nutrient starvation and ischemia/hypoxia, and modulates many aspects of mammalian cell metabolism. The AMPK yeast homolog, Snf1p, plays a major role in adaption to glucose deprivation. In mammals, AMPK also has diverse roles that extend from energy metabolism through to transcriptional control.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • AMP-Activated Protein Kinases
  • Cholesterol / biosynthesis
  • Creatine Kinase / metabolism
  • Energy Metabolism
  • Fatty Acids / metabolism
  • Glucose / metabolism
  • Isoenzymes / chemistry
  • Isoenzymes / metabolism
  • Multienzyme Complexes / chemistry
  • Multienzyme Complexes / metabolism*
  • Protein Conformation
  • Protein Kinases / chemistry
  • Protein Kinases / metabolism*
  • Protein-Serine-Threonine Kinases / chemistry
  • Protein-Serine-Threonine Kinases / metabolism

Substances

  • Fatty Acids
  • Isoenzymes
  • Multienzyme Complexes
  • Cholesterol
  • Protein Kinases
  • SNF1-related protein kinases
  • Protein-Serine-Threonine Kinases
  • AMP-Activated Protein Kinases
  • Creatine Kinase
  • Glucose