Abstract
Analysis of embryonic induction has pointed to the importance of the antagonistic roles played by secreted inducing factors and their soluble inhibitory binding proteins. These interactions have been particularly well characterized in patterning the primary axes of insects and vertebrates. New results implicate similar antagonistic relationships in numerous later events of embryogenesis.
MeSH terms
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Animals
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Bone Morphogenetic Proteins / physiology
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Carrier Proteins
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Congenital Abnormalities / genetics
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Embryonic and Fetal Development / physiology*
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Extremities / embryology
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Fetal Proteins / physiology
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Follistatin
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Glycoproteins / physiology
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Hedgehog Proteins
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Intercellular Signaling Peptides and Proteins*
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Mice
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Mice, Knockout
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Models, Biological
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Morphogenesis / physiology
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Multigene Family
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Proteins / physiology
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Signal Transduction
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Somites / physiology
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Trans-Activators*
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Transforming Growth Factor beta / antagonists & inhibitors*
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Transforming Growth Factor beta / physiology
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Xenopus laevis / embryology
Substances
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Bone Morphogenetic Proteins
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Carrier Proteins
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Fetal Proteins
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Follistatin
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Glycoproteins
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Hedgehog Proteins
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Intercellular Signaling Peptides and Proteins
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Proteins
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Trans-Activators
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Transforming Growth Factor beta
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noggin protein
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chordin