Feasting, Fasting and Fermenting. Glucose Sensing in Yeast and Other Cells

Trends Genet. 1999 Jan;15(1):29-33. doi: 10.1016/s0168-9525(98)01637-0.

Abstract

Glucose is the primary fuel for most cells. Because the amount of available glucose can fluctuate wildly, organisms must sense the amount available to them and respond appropriately. Altering gene expression is one of the major effects glucose has on cells. Two different glucose sensing and signal transduction pathways in the yeast S. cerevisiae--one for repression, and one for induction of gene expression--have recently come into focus. What we have learned about these glucose sensing and signaling mechanisms might shed light on how other cells sense and respond to glucose.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphate / biosynthesis
  • Animals
  • Carrier Proteins / genetics
  • Carrier Proteins / physiology
  • Eating
  • Energy Metabolism
  • Fasting
  • Fermentation
  • Fungal Proteins / genetics
  • Fungal Proteins / physiology
  • Gene Expression Regulation, Fungal* / drug effects
  • Glucose / metabolism*
  • Glucose / pharmacology
  • Humans
  • Macromolecular Substances
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology
  • Models, Biological
  • Repressor Proteins / genetics
  • Repressor Proteins / physiology
  • Saccharomyces cerevisiae / drug effects
  • Saccharomyces cerevisiae / genetics
  • Saccharomyces cerevisiae / metabolism*
  • Signal Transduction / drug effects
  • Signal Transduction / genetics
  • Signal Transduction / physiology*
  • Transcription Factors / genetics
  • Transcription Factors / physiology

Substances

  • Carrier Proteins
  • Fungal Proteins
  • Macromolecular Substances
  • Membrane Proteins
  • Repressor Proteins
  • Transcription Factors
  • Adenosine Triphosphate
  • Glucose