Commentary: low-dose high-frequency enzyme replacement therapy prevents fractures without complete suppression of painful bone crises in patients with severe juvenile onset type I Gaucher disease

MeSH terms

• Adolescent
• Adult
• Age Factors
• Animals
• Anti-Inflammatory Agents / adverse effects
• Anti-Inflammatory Agents / therapeutic use
• Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
• Bone Development
• Child
• Female
• Femur Head Necrosis / etiology
• Femur Head Necrosis / prevention & control
• Fractures, Spontaneous / etiology
• Fractures, Spontaneous / prevention & control*
• Gaucher Disease / classification
• Gaucher Disease / complications
• Gaucher Disease / drug therapy*
• Gaucher Disease / enzymology
• Gaucher Disease / genetics
• Glucosylceramidase / administration & dosage
• Glucosylceramidase / therapeutic use*
• Heterozygote
• Humans
• Male
• Osteonecrosis / etiology
• Osteonecrosis / prevention & control
• Pain / drug therapy
• Pain / etiology
• Prednisolone / therapeutic use
• Prednisone / adverse effects
• Prednisone / therapeutic use
• Rats
• Research Design